BPC-157¶
BPC-157 (Body Protection Compound-157, CAS 137525-51-0) is a synthetic pentadecapeptide fragment (BPC 15) derived from a protective protein found in human gastric juice, with a molecular weight of 1,419.5 Da and formula C₆₂H₉₈N₁₆O₂₂. As a partial sequence of body protection compound (BPC), this peptide exhibits remarkable stability against hydrolysis and gastric degradation — surviving intact in gastric juice for over 24 hours. BPC-157 is among the most extensively studied cytoprotective peptides for tissue repair, angiogenesis, and gastrointestinal mucosal protection research.
Technical Specifications¶
| Property | Value |
|---|---|
| CAS Number | 137525-51-0 |
| Molecular Formula | C₆₂H₉₈N₁₆O₂₂ |
| Molecular Weight | 1,419.5 Da |
| Purity | ≥99% (HPLC-verified) |
| Appearance | Lyophilized white powder |
| Solubility | Soluble in sterile water and aqueous buffers |
| Storage | -20°C (lyophilized), 2–8°C (reconstituted) |
Mechanism of Action¶
BPC-157 promotes tissue repair through multiple complementary mechanisms. It upregulates vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) expression and activates the VEGFR2-Akt-eNOS signaling pathway, stimulating angiogenesis — the formation of new blood vessels from existing vasculature — critical for wound granulation. Concurrently, BPC-157 enhances fibroblast migration and proliferation via FAK-paxillin pathway activation, accelerating collagen deposition and extracellular matrix remodeling at injury sites. In the gastrointestinal system, BPC-157 maintains endothelial integrity by preserving tight junction protein expression (occludin, claudin-1, ZO-1) and counteracting the effects of NSAID-induced COX inhibition. The peptide also interacts with the dopaminergic system through indirect modulation, and has been shown to accelerate peripheral nerve regeneration by promoting Schwann cell migration and axonal sprouting in rodent nerve injury models.
Research Applications¶
- Primary: Tissue repair and wound healing — angiogenesis, fibroblast activation, collagen synthesis
- Secondary: Gastrointestinal mucosal protection (NSAID-induced injury models), tendon/ligament repair, neuroprotection and nerve regeneration
- Model Systems: In vitro (HUVEC angiogenesis assays, fibroblast scratch assays), in vivo rodent models (Achilles tendon transection, gastric ulcer models, sciatic nerve crush injury)
Quality Control & Analytical Methods¶
- HPLC: ≥99% purity verification at 214/220 nm (C18 reversed-phase column)
- Mass Spectrometry: ESI-MS for molecular weight confirmation (1,419.5 ±1.0 Da)
- Peptide Content: Amino acid analysis (AAA) for net peptide content determination
- Endotoxin: <1 EU/mg (LAL assay)
- TFA Content: <1% (ion chromatography)
Stability & Storage¶
| Condition | Stability |
|---|---|
| -20°C (lyophilized) | 24 months |
| 4°C (lyophilized) | 6 months |
| 25°C (lyophilized) | 1 month |
| Reconstituted (4°C) | 7 days |
| Reconstituted (-20°C) | 30 days |
Key Research References¶
- Sikiric et al. (2011) — BPC 157: a novel peptide with cytoprotective and wound healing effects. Curr Pharm Des. PMID: 21548875
- Hsieh et al. (2017) — BPC-157 promotes angiogenesis and accelerates wound healing. J Surg Res. PMID: 28088026
- Chang et al. (2015) — BPC-157 accelerates recovery from Achilles tendon injury. Am J Sports Med. PMID: 25189379
Source & Purchase¶
For researchers requiring research-grade BPC 157 with full analytical documentation including HPLC, LC-MS, and Certificate of Analysis, visit the HK Peptides product page for specifications, bulk pricing, and ordering.
Related Molecules¶
- TB-500 — Thymosin Beta-4 fragment, cell migration
- KPV — Anti-inflammatory tripeptide
- GHK-Cu — Copper peptide, wound healing
- All Product Specifications
FAQ¶
Q: What purity level is standard for BPC-157? A: HK Peptides supplies BPC-157 at ≥99% purity by HPLC with full COA documentation.
Q: How should BPC-157 be stored for research use? A: Lyophilized BPC-157 should be stored at -20°C. Reconstituted solutions at 4°C for short-term use (up to 7 days).